Ask the expert: Why the mulligan for the hepatitis B vaccination?

By: August 24th, 2010 Email This Post Print This Post

Q: What is the reason for having to re-administer the hepatitis B vaccination when a worker fails to respond to the first three-shot series?

A: According to the U.S. Public Health Service (USPHS), 50-75% of nonresponders will respond to a three-dose revaccination series. Given that rate of success, the USPHS guidelines call for a second series after an inadequate response to the first vaccination series.

The OSHA bloodborne pathogens standard, 1910.1030(f)(1)(ii)(D), requires employers to follow the USPHS guidelines for hepatitis B vaccination and post-exposure evaluation and follow-up.

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Comments

By Sharon Rich on August 24th, 2010 at 11:46 am

If the HCW did not have a HBSAB drawn after the vaccine was completed, how long afterward could we assume that the HCW is a responder/ nonresponder? Many titers wane after years and are no longer detectable. How do we know the HCW continues to be protected?

By David LaHoda on August 24th, 2010 at 12:36 pm

If the healthcare worker did not have a titer, you must assume non-responder status according to the CDC/USPHS guidelines (See Table 3).

With regard to serologic testing, and boosters, the same source says:

“Booster doses of hepatitis B vaccine are not necessary, and periodic serologic testing to monitor antibody concentrations after completion of the vaccine series is not recommended. Any blood or body fluid exposure sustained by an unvaccinated, susceptible person should lead to the initiation of the hepatitis B vaccine series.”

Note the use of the word “periodic,” which means other than the titer drawn one to tow months after vaccination, in the citation above.

A November 9, 2005 letter of interpretation confirms this recommendation for OSHA compliance purposes.

“Hepatitis B and the healthcare worker,” from the IAC does a good job of explaining how you can still have immunity despite a low titer years after your vaccination.

By Jeanette Lametta on September 7th, 2010 at 9:28 am

I was one of those who was a non-responder after my 1st series but became reactive and immune after completion of the 2nd. Five years later, I come up non-reactive however CDC states I do not require any more “boosters” or another series as the antibodies would surface upon an exposure.

 

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