Pharmaceutical company halts Alzheimer’s clinical trials
Eli Lilly, an Indianapolis-based pharmaceutical company working towards developing a clinical Alzheimer’s disease treatment, ended two late-stage experimental trials on August 17. Patients who took the drug displayed worse cognitive functioning and a decreased ability to perform activities of daily living than patients who took the placebo, according to The New York Times.
The drug, semagacestat, is intended to reduce the production of amyloid beta plaques in the brain, which is thought to be a potential cause of Alzheimer’s disease. But the trials, which began in 2008, showed that an excessive reduction of plaques may damage cognitive functions. Lilly is already testing a different drug—an intravenous monoclonal antibody—that reduces the plaques, and the company plans on following the 2,600 Alzheimer’s patients who participated in the trials for six more months.
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MacKenzie Kimball
MacKenzie Kimball is a Managing Editor in HCPro's long-term care division. She is the editor of the monthly newsletter PPS Alert for Long-Term Care and the MDS 3.0 Update e-newsletter.
MacKenzie has written 321 posts.
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